This requires at least 60 Affection. Once met, a dialogue option will appear on a weekend morning inviting her out.
During this phase, Shizune will catch you searching through files or interacting with Tsunade late at night.
A Harem Adventure: A Walkthrough of Living with Tsunade v040 Living with Tsunade v040 Walkthrough SOCIGAMES
When Tsunade offers a drink on Day 5, choose "Drink with her responsibly." Do not push boundaries too early, or you will trigger a premature game over. Mid-Game: Days 11 to 25 (Unlocking v0.4.0 Events)
Don't skimp on food. Keep food items bought from the market in your inventory to restore your energy without wasting a whole day sleeping. This requires at least 60 Affection
Tsunade politely asks you to leave. You return to the Hidden Leaf, mission failed. No CG.
Tsunade has a hidden "Thirst Meter" (1-10). A Harem Adventure: A Walkthrough of Living with
Interact with Tsunade in the Living Room on Friday night. Select "Offer her the Premium Sake." The Conversation Flow:
Once you reach an Affection level of 30+, new interactions unlock.